Review





Similar Products

trax point mutant mouse line  (Jackson Laboratory)
86
Jackson Laboratory trax point mutant mouse line
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Trax Point Mutant Mouse Line, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pmc13266039-285-2-14?v=Jackson+Laboratory
Average 86 stars, based on 1 article reviews
trax point mutant mouse line - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
m2 1 lysine mutants  (Sangon Biotech)
86
Sangon Biotech m2 1 lysine mutants
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
M2 1 Lysine Mutants, supplied by Sangon Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42286185-186-40-51?v=Sangon+Biotech
Average 86 stars, based on 1 article reviews
m2 1 lysine mutants - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
scaf8 mutant protein plasmids  (Servicebio Inc)
86
Servicebio Inc scaf8 mutant protein plasmids
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Scaf8 Mutant Protein Plasmids, supplied by Servicebio Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42288759-173-0-22?v=Servicebio+Inc
Average 86 stars, based on 1 article reviews
scaf8 mutant protein plasmids - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
mutant slc25a46  (Koehler Instrument)
86
Koehler Instrument mutant slc25a46
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Mutant Slc25a46, supplied by Koehler Instrument, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42288900-622-17-12?v=Koehler+Instrument
Average 86 stars, based on 1 article reviews
mutant slc25a46 - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
nin 1 medicago truncatula ecotype a17 mutant nfya1 1 laporte  (Medicago)
86
Medicago nin 1 medicago truncatula ecotype a17 mutant nfya1 1 laporte
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Nin 1 Medicago Truncatula Ecotype A17 Mutant Nfya1 1 Laporte, supplied by Medicago, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42263681-227-56-57?v=Medicago
Average 86 stars, based on 1 article reviews
nin 1 medicago truncatula ecotype a17 mutant nfya1 1 laporte - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
dmi3 medicago truncatula ecotype a17 mutant cre1 1 plet  (Medicago)
86
Medicago dmi3 medicago truncatula ecotype a17 mutant cre1 1 plet
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Dmi3 Medicago Truncatula Ecotype A17 Mutant Cre1 1 Plet, supplied by Medicago, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42263681-227-36-37?v=Medicago
Average 86 stars, based on 1 article reviews
dmi3 medicago truncatula ecotype a17 mutant cre1 1 plet - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
nfp medicago truncatula dmi1 b129 mutant ané  (Medicago)
86
Medicago nfp medicago truncatula dmi1 b129 mutant ané
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Nfp Medicago Truncatula Dmi1 B129 Mutant Ané, supplied by Medicago, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42263681-227-12-13?v=Medicago
Average 86 stars, based on 1 article reviews
nfp medicago truncatula dmi1 b129 mutant ané - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
dmi1 medicago truncatula dmi2 tr25 mutant stracke  (Medicago)
86
Medicago dmi1 medicago truncatula dmi2 tr25 mutant stracke
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Dmi1 Medicago Truncatula Dmi2 Tr25 Mutant Stracke, supplied by Medicago, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42263681-227-20-21?v=Medicago
Average 86 stars, based on 1 article reviews
dmi1 medicago truncatula dmi2 tr25 mutant stracke - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
dmi2 medicago truncatula dmi3 trv25 mutant wais  (Medicago)
86
Medicago dmi2 medicago truncatula dmi3 trv25 mutant wais
Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
Dmi2 Medicago Truncatula Dmi3 Trv25 Mutant Wais, supplied by Medicago, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mutants/pm42263681-227-28-29?v=Medicago
Average 86 stars, based on 1 article reviews
dmi2 medicago truncatula dmi3 trv25 mutant wais - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier

Image Search Results


Abolishing the RNase activity of Trax leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.

Journal: iScience

Article Title: Genetic inactivation of Translin/Trax RNase disrupts miRNAs, hippocampal synaptic plasticity, and memory

doi: 10.1016/j.isci.2026.116188

Figure Lengend Snippet: Abolishing the RNase activity of Trax leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.

Article Snippet: • The Trax point-mutant mouse line used in this study (TraxE126A) is cryopreserved at the Jackson Laboratory (C57BL/6-Tsnax em1Jbar /J; Strain #035903) and is available by cryorecovery.

Techniques: Activity Assay, Expressing, Functional Assay